PGD Treatment in Bangalore - Test Your Embryo Before Transfer
Preimplantation Genetic Diagnosis (PGD) is an advanced procedure performed during IVF that tests embryos for chromosomal abnormalities before they are transferred to the uterus significantly improving your chance of a successful, healthy pregnancy.
Available at Janisthaa Fertility and IVF Center, Basaveshwarnagar, Bengaluru, under Dr. Shwetha Y. Baratikkae – IVF Specialist.
You may need PGD if you have
- 2 or more recurrent miscarriages
- 2+ failed IVF cycles without explanation
- A known chromosomal or genetic condition
- Advanced maternal age (37+)
- A family history of hereditary disorders
- A previous child with chromosomal abnormality
PGD eligibility is determined after clinical evaluation. Book a consultation withDr. Shwetha to assess your specific case.
Preimplantation Genetic Diagnosis (PGD)
PGD — short for Preimplantation Genetic Diagnosis is a scientific process that examines the genetic and chromosomal composition of embryos created during an IVF cycle before any embryo is transferred to the uterus.
The fundamental goal of PGD is to identify embryos that are chromosomally normal (“euploid”) and free of specific genetic disorders, so only those with the highest chance of successful implantation and a healthy pregnancy are transferred.
In simple terms: PGD helps you and your doctor choose the right embryo not by appearance, but by genetic science.
PGD analyses the chromosomes inside embryo cells — not visible on any scan or by embryo grading alone.
🛡️ Reduces chromosomal miscarriage risk
50–60% of first-trimester miscarriages are caused by chromosomal abnormalities. PGD identifies and excludes these embryos before transfer.
By transferring only chromosomally normal embryos, PGD improves implantation rates — especially in women over 37.
Preimplantation Genetic Diagnosis (PGD), now referred to under the broader term Preimplantation Genetic Testing (PGT) is a laboratory procedure performed in conjunction with in vitro fertilisation (IVF). On Day 5 of embryo development (blastocyst stage), a small number of trophectoderm cells are biopsied from each embryo and sent for chromosomal or genetic analysis using Next-Generation Sequencing (NGS) or Comparative Genomic Hybridisation (CGH) technology.
Results identify whether each embryo carries the correct number of chromosomes (46 in humans) and/or is free of specific single-gene disorders. Only chromosomally normal embryos are selected for frozen embryo transfer (FET) in a subsequent cycle.
Source: ESHRE PGT Consortium Guidelines; ASRM Committee Opinion on PGT; WHO Reproductive Health Framework.
Sex selection through PGD for non-medical reasons is prohibited in India under the PCPNDT Act, 1994.
At Janisthaa IVF, PGD is performed exclusively for medically indicated genetic screening.
PGD, PGS, PGT - What Is the Difference?
The terminology around embryo genetic testing has evolved. PGD and PGS are now collectively referred to as PGT (Preimplantation Genetic Testing) — with three subtypes depending on what is being tested. At Janisthaa IVF Bangalore, Dr. Shwetha Y. Baratikkae recommends the appropriate type based on your clinical history.
PGT-A
Aneuploidy Screening
Tests embryos for the correct number of chromosomes (46). Identifies aneuploid embryos — those with too many or too few chromosomes — which cause miscarriage and IVF failure.
Formerly called: PGS (Preimplantation Genetic Screening)
Best for: Women 37+, recurrent miscarriage, repeated IVF failure.
PGT-M
Monogenic Disorders
Tests embryos for specific single-gene disorders such as cystic fibrosis, sickle cell anaemia, thalassemia, Huntington’s disease, and other inherited conditions.
Formerly called: PGD for monogenic disorders
Best for: Couples with known hereditary single-gene disorders.
PGT-SR
Structural Rearrangements
Tests embryos where one or both parents carries a chromosomal structural rearrangement (translocation or inversion) that may result in unbalanced chromosomes in offspring.
Formerly called: PGD for chromosomal rearrangements
Best for: Couples with confirmed chromosomal translocations.
Is PGD Right for You? - 6 Clinical Indications
PGD is not required for every IVF cycle. At Janisthaa Fertility and IVF Center, Bangalore, Dr. Shwetha Y. Baratikkae recommends PGD based on your specific clinical history and risk factors. These are the primary indications:
✔️ Recurrent pregnancy loss (2+ miscarriages)
Approximately 50% of recurrent miscarriages are caused by chromosomally abnormal embryos. PGD identifies and eliminates these before transfer, significantly reducing miscarriage risk in your next pregnancy.
✔️ Advanced maternal age (37 years and above)
The incidence of chromosomally abnormal embryos increases significantly with maternal age. By 40, over 50% of embryos may be aneuploid. PGD selects the healthy ones, improving success rates markedly.
✔️ Hereditary single-gene disorder
Couples who carry conditions like thalassemia, sickle cell disease, cystic fibrosis, Huntington's disease, or spinal muscular atrophy can use PGT-M to select embryos that will not be affected by these conditions.
✔️ Repeated IVF failure (2+ failed cycles)
If previous IVF cycles have failed despite good-looking embryos, chromosomal abnormality is a leading cause. PGD finds what cannot be seen by embryo grading alone.
✔️ Known chromosomal translocation (parent)
If either parent carries a balanced chromosomal rearrangement (translocation or inversion), there is a significant risk of unbalanced chromosomes in embryos. PGT-SR identifies which embryos are chromosomally balanced.
✔️ Previous child with chromosomal condition
Couples who have had a child with a chromosomal disorder such as Down syndrome, Edwards syndrome, or Patau syndrome are at higher risk in future pregnancies. PGD significantly reduces this risk.
The PGD Process at Janisthaa IVF Bangalore - Step by Step
PGD is integrated into your IVF cycle. Here is exactly what happens at Janisthaa Fertility and IVF Center, Basaveshwarnagar, Bengaluru:
Ovarian Stimulation
Egg Retrieval & Fertilisation
Embryo Culture & Biopsy
Genetic Analysis
Frozen Embryo Transfer
PGD Results – What the Report Tells You
Euploid
Correct number of chromosomes (46). Chromosomally normal embryo.
Suitable for Transfer? Yes — preferred.
Action at Janisthaa IVF: Selected for frozen embryo transfer in the next cycle.
Aneuploid
Incorrect chromosome number — too many or too few. A common cause of IVF failure and miscarriage.
Suitable for Transfer? No.
Action at Janisthaa IVF: Not transferred. Discarded with informed consent.
Mosaic
Mix of normal and abnormal cells. Some mosaic embryos can implant successfully.
Suitable for Transfer? Sometimes.
Action at Janisthaa IVF: Discussed with Dr. Shwetha Y. Baratikkae. May be transferred if no euploid embryos are available, with full counselling.
No Result
Insufficient DNA from biopsy for conclusive analysis. Rare.
Suitable for Transfer? Uncertain.
Action at Janisthaa IVF: Re-biopsy may be discussed or embryo considered unsuitable. Managed case by case.
All PGD results and embryo transfer decisions are explained in a detailed consultation with Dr. Shwetha Y. Baratikkae before any embryo is transferred.
IVF Without PGD vs IVF With PGD — Key Differences
✗ IVF Without PGD
- Embryo selected by appearance only (grading)
- Chromosomal abnormalities are invisible — cannot be detected
- Abnormal embryos may be transferred unknowingly
- Higher risk of failed implantation
- Higher miscarriage risk if abnormal embryo implants
- No information on genetic health of embryos
- Outcome uncertainty — repeated failures may remain unexplained
✓ IVF With PGD
- Embryo selected by genetic analysis science, not appearance
- Chromosomal composition known before transfer
- Only chromosomally normal embryos transferred
- Significantly higher implantation success rate
- Significantly lower miscarriage risk
- Identifies specific single-gene disorders (PGT-M)
- Clear scientific reason for each outcome - no unexplained failures
PGD Treatment Cost in Bangalore -Transparent Pricing
PGD cost in Bangalore varies depending on the type of genetic testing required (PGT-A, PGT-M, or PGT-SR), the number of embryos tested, and the laboratory partner. At Janisthaa IVF, we provide complete cost transparency before any procedure begins – no hidden charges.
PGT-A (Aneuploidy Screening)
Per IVF cycle, for up to 5 embryos biopsied. Additional embryos billed per embryo. Does not include the IVF cycle cost.
- Embryo biopsy by senior embryologist
- NGS / array CGH chromosomal analysis
- Written genetic report per embryo
- Pre-transfer counselling with Dr. Shwetha
Most commonly recommended. Covers chromosomal number abnormalities.
PGT-M (Single-Gene Disorders)
Cost varies significantly based on the specific gene disorder being tested, probe design, and number of embryos. Requires pre-cycle genetic workup (3–6 months prior).
- Pre-cycle genetic counselling
- Custom probe / primer design for specific mutation
- Embryo biopsy and genetic testing
- Written report and transfer planning consultation
Required when a known hereditary single-gene disorder is present in the family.
Total Cost of IVF + PGD in Bangalore – What to Budget
The total cost for an IVF cycle with PGD at Janisthaa IVF, Basaveshwarnagar, Bengaluru, including stimulation medications, egg retrieval, ICSI, embryo culture, PGT-A biopsy and analysis, vitrification, and frozen embryo transfer (FET), typically ranges from ₹1,80,000 to ₹2,80,000. This is significantly more cost-effective than multiple failed IVF attempts without PGD.
Note: Every patient’s cost estimate is personalised. Book a free consultation with Dr. Shwetha Y. Baratikkae for an exact treatment plan and cost breakdown based on your specific medical profile.
Meet Dr. Shwetha Y. Baratikkae — IVF & PGD Specialist, Bangalore
Dr. Shwetha Y. Baratikkae
MBBS, MS (Obstetrics & Gynaecology)
· IVF Specialist · Consultant Reproductive Medicine · Janisthaa Fertility and IVF Center, Basaveshwarnagar, Bengaluru
Dr. Shwetha Y. Baratikkae is a dedicated IVF Specialist and Gynaecologist with deep expertise in advanced reproductive medicine including PGD, recurrent miscarriage management, male factor infertility, and complex IVF protocols. Patients across Karnataka, Andhra Pradesh, and Tamil Nadu seek her specifically for cases where other clinics have not found answers.
Dr. Shwetha’s approach to PGD: “PGD does not guarantee a pregnancy. What it guarantees is that when we transfer an embryo, we know its genetic health and that knowledge transforms outcomes for the patients who need it most.”
- 5,000+ Families helped
- PGD Advanced specialist
- 3 Clinics Across Bengaluru
PGD Treatment in Bangalore - Most Asked Questions
What is PGD treatment in Bangalore?
PGD (Preimplantation Genetic Diagnosis) is an advanced IVF procedure available in Bangalore that tests embryos for chromosomal abnormalities and genetic disorders before they are transferred to the uterus. In Bangalore, PGD is available at Janisthaa Fertility and IVF Center, Basaveshwarnagar, under Dr. Shwetha Y. Baratikkae — IVF Specialist.
The procedure involves: creating embryos through standard IVF → culturing them to Day 5 → biopsying a small number of cells → sending cells for genetic analysis → transferring only the chromosomally normal embryo in a subsequent frozen embryo transfer cycle.
What is the cost of PGD treatment in Bangalore?
PGD cost in Bangalore (PGT-A / aneuploidy screening) ranges from ₹40,000 to ₹60,000 for up to 5 embryos, in addition to the IVF cycle cost. PGT-M (single-gene disorder testing) costs ₹80,000 to ₹1,50,000 due to the need for custom probe design.
The total cost of IVF + PGD in Bangalore at Janisthaa IVF ranges from approximately ₹1,80,000 to ₹2,80,000 for a complete cycle. At Janisthaa Fertility and IVF Center, Basaveshwarnagar, all costs are disclosed upfront — no hidden charges. Book a free consultation with Dr. Shwetha Y. Baratikkae for a personalised cost estimate.
Who is PGD recommended for?
PGD is recommended for: (1) Couples with 2 or more recurrent miscarriages, (2) Couples with 2+ failed IVF cycles, (3) Women above 37 years where chromosomal risk in embryos is significantly higher, (4) Couples with a known genetic or chromosomal disorder, (5) Couples who have had a child with a chromosomal condition such as Down syndrome, (6) Couples with a family history of hereditary genetic diseases such as thalassemia, cystic fibrosis, or sickle cell anaemia.
Does PGD improve IVF success rates?
Yes. PGD improves IVF success rates by ensuring only chromosomally normal (euploid) embryos are transferred. For women over 37, PGD can improve per-transfer success rates by 10–20%. For couples with recurrent IVF failure or pregnancy loss, PGD can identify the chromosomal cause that was previously invisible — transforming outcomes.
However, PGD does not guarantee a successful pregnancy. Success depends on multiple factors including uterine receptivity, age, and overall health. Dr. Shwetha Y. Baratikkae provides realistic outcome expectations during consultation.
What is the difference between PGD and PGS?
PGD and PGS are now both classified under PGT (Preimplantation Genetic Testing): PGT-M (formerly PGD) tests for specific single-gene disorders. PGT-A (formerly PGS) tests for chromosomal number abnormalities (aneuploidies). PGT-SR tests for chromosomal structural rearrangements.
At Janisthaa IVF Bangalore, Dr. Shwetha Y. Baratikkae recommends the appropriate type of PGT based on your medical history and the specific reason for testing.
How long does PGD take during an IVF cycle?
The IVF stimulation phase takes 10–14 days. Embryos are cultured for 5–6 days to blastocyst stage, then biopsied. Genetic analysis results take 10–14 days. All biopsied embryos are frozen (vitrified) during this waiting period. The chromosomally normal embryo is transferred in a subsequent frozen embryo transfer (FET) cycle, typically 4–6 weeks later. The total process from start to transfer is approximately 2–3 months.
Is PGD safe for the embryo?
Yes. PGD biopsy is performed on Day-5 blastocyst embryos, which contain hundreds of cells. The 5–8 cells removed represent a very small fraction of the embryo and do not affect its development or viability. Extensive research including large multi-centre studies confirms that babies born from PGD-tested embryos show no higher incidence of birth defects or developmental issues compared to those from standard IVF.
Can PGD prevent miscarriage?
PGD significantly reduces the risk of miscarriage caused by chromosomal abnormalities, which account for approximately 50–60% of first-trimester miscarriages. For couples with recurrent pregnancy loss, PGD reduces — but does not eliminate — miscarriage risk, since other causes (uterine, immunological, hormonal, thrombophilia) also contribute to miscarriage.
At Janisthaa IVF Bangalore, Dr. Shwetha Y. Baratikkae conducts a comprehensive evaluation for recurrent miscarriage — investigating all possible causes in addition to embryo chromosomal health — to give you the best possible outcome.
Which is the best clinic for PGD treatment in Bangalore?
Janisthaa Fertility and IVF Center, Basaveshwarnagar, Bengaluru, is one of the leading clinics for PGD treatment in Bangalore, offering advanced embryo genetic testing under Dr. Shwetha Y. Baratikkae — a dedicated IVF Specialist with extensive experience in PGD, recurrent miscarriage management, and complex fertility cases.
When choosing a clinic for PGD in Bangalore, look for: (1) A dedicated IVF specialist managing your case, (2) An in-house embryology lab with experienced embryologists for biopsy, (3) A clear genetic laboratory partner with accreditation, (4) Transparent pricing with no hidden charges, (5) Experience with your specific indication (recurrent loss, IVF failure, or hereditary disorder).
Can PGD determine the gender of the baby?
PGD analysis does identify sex chromosomes as part of chromosomal testing. However, sex selection for non-medical reasons is strictly illegal in India under the PCPNDT Act, 1994, and is not offered or discussed at Janisthaa IVF Bangalore. PGD is performed exclusively for medically indicated genetic screening to improve the chance of a healthy pregnancy.
Ready to Know If PGD Is Right for You?
Book a free consultation with Dr. Shwetha Y. Baratikkae – IVF Specialist, Janisthaa Fertility and IVF Center, Basaveshwarnagar, Bengaluru. She will review your history, explain whether PGD is indicated for your specific case, and give you an honest recommendation.