Who Needs IVF with ICSI?
ICSI is recommended when:
- Low sperm count (oligospermia) — below 5–10 million/mL, where natural IVF fertilisation is unlikely
- Poor sperm motility (asthenospermia) — less than 20% progressive motility
- Poor sperm morphology (teratospermia) — less than 2–4% normal forms
- Azoospermia — zero sperm in ejaculate; sperm retrieved via TESA or PESA must be used with ICSI
- High DNA fragmentation (DFI > 25%) — ICSI allows individual sperm selection to minimise this factor
- Previous IVF fertilisation failure — if eggs failed to fertilise naturally in a prior cycle
- Very few eggs retrieved — when only 2–5 mature eggs are available, ICSI maximises each opportunity
- Frozen/thawed sperm — cryopreserved sperm (cancer patients, sperm banking) is used with ICSI
You may NOT need ICSI if: sperm count, motility, and morphology are all normal, this is a first IVF cycle with no prior fertilisation issues, and female factor is the primary cause. Standard IVF may be sufficient — Dr. Shwetha will confirm based on your specific semen analysis.
Not sure if you need ICSI or standard IVF?
Dr. Shwetha reviews your semen analysis and recommends the right approach before any treatment begins.
ICSI Success Rate in Bangalore - What to Expect by Age
| Stage | Typical Rate |
|---|
| Egg Survival After ICSI Injection | 90–95% |
| Fertilisation Rate (2PN Formation) | 70–85% of mature eggs |
| Blastocyst Development Rate | 40–60% of fertilised eggs |
| Female Age | Clinical Pregnancy Rate per Cycle |
|---|
| Under 35 years | 50–65% |
| 35–37 years | 40–50% |
| 38–40 years | 30–40% |
| 41–42 years | 20–30% |
| Over 42 years | 10–20% (Donor egg IVF is often recommended to improve success rates.) |
IVF with ICSI vs Standard IVF - When Does ICSI Make the Difference?
| Feature | Standard IVF | IVF with ICSI |
|---|
| Fertilisation Method | Sperm fertilises the egg naturally in the laboratory dish | A single sperm is injected directly into the egg |
| Sperm Count Needed | ≥1 million motile sperm/mL | Any count, even 1 viable sperm may be sufficient |
| Best For | Normal semen analysis and female factor infertility | Male factor infertility, azoospermia, or previous IVF fertilisation failure |
| Fertilisation Rate | 50–70% of eggs | 70–85% of eggs |
| Cost at Janisthaa IVF | ₹80,000–₹1,20,000 per cycle | ₹1,00,000–₹1,60,000 per cycle |
| Can Use Surgically Retrieved Sperm? | No | Yes (TESA/PESA) |
ICSI makes the most difference precisely where standard IVF would otherwise fail at the fertilisation step male factor cases. For pure female-factor infertility with normal sperm, standard IVF fertilisation rates are already comparable, so ICSI’s main benefit there is marginal and not always worth the added cost.
ICSI with PESA - For Men with Obstructive Azoospermia
PESA (Percutaneous Epididymal Sperm Aspiration) retrieves sperm from the epididymis — used specifically for obstructive azoospermia where a blockage prevents sperm from reaching the ejaculate. PESA is less invasive than TESA and is typically the first-line option when the cause is a confirmed blockage rather than a production issue.
Diagnosed with azoospermia? Zero sperm doesn’t mean zero options.
TESA/PESA + ICSI has helped many couples at Janisthaa IVF achieve biological parenthood.
What Happens During the ICSI Procedure - Step by Step
- Ovarian Stimulation (Days 1–12): Daily hormone injections stimulate multiple follicle development, monitored every 2–3 days.
- Egg Retrieval: When follicles reach 18–20mm, a trigger injection is given and eggs are collected 35–36 hours later under sedation. Male partner provides a semen sample same day (or TESA/PESA sperm is used).
- Sperm Preparation: The sample is processed using density gradient centrifugation to isolate the best-quality motile sperm.
- ICSI Fertilisation: Under a micromanipulation microscope, the embryologist selects a single normal, motile sperm, immobilises it, and injects it directly into each mature egg’s cytoplasm. Takes 10–15 minutes per batch.
- Fertilisation Check (Day 1): Injected eggs are checked the following morning for successful fertilisation (2PN formation).
- Embryo Culture (Days 1–5): Fertilised eggs are cultured until they reach blastocyst stage — the highest-implantation-potential stage.
- Embryo Transfer: The best-quality blastocyst is transferred via a fine catheter under ultrasound guidance — a 10-minute procedure requiring no anaesthesia.
- Pregnancy Test: A beta-hCG blood test 10–12 days after transfer confirms pregnancy, with a repeat test 48 hours later to confirm appropriate doubling.
Janisthaa IVF's ICSI Lab - What Makes Ours Different
ICSI is performed in our dedicated embryology laboratory at all three Bangalore centres, by trained embryologists using micromanipulation equipment specifically calibrated for sperm injection precision. We also offer IMSI (Intracytoplasmic Morphologically Selected Sperm Injection) — an enhanced version of ICSI examining sperm at 6,000× magnification versus the standard 400×, used for high DNA fragmentation, repeated ICSI fertilisation failure, or severe teratospermia.
Every couple receives a full written, itemised cost estimate before treatment begins — there are no mid-cycle surprises at Janisthaa IVF.
Frequently Asked Questions - ICSI Cost Bangalore
Book Your ICSI Consultation at Janisthaa IVF - 3 Bangalore Centres
| Centre | Address | Contact |
|---|
| Basaveshwaranagar (Main) | 2nd Block, No. 2, 1st Main Road, Basaveshwaranagar, Bengaluru – 560079 | +91 95911 11407 |
| RR Nagar | No. 1601, 1st Main Road, BEML Layout, RR Nagar, Bengaluru – 560098 | +91 90356 81162 |
| Nagarbhavi | 525, second floor, GM building, Naagarabaavi 14th Block, 14th Block, NGEF Layout, Nagarbhavi, Bengaluru, Karnataka 560072. | +91 90356 81163 |